In December 2024, the U.S. Environmental Protection Agency (EPA) announced a 10-year phaseout for the use of perchloroethylene (PCE), although most uses will be fully phased out in less than three years. PCE is a solvent used for consumer applications, such as brake cleaners and adhesives, as well as for industrial uses, such as dry cleaning, the production of refrigerants and the processing of petroleum at refineries.

Newly acquired dry-cleaning machines are prohibited from using PCE after six months. The compliance dates for machines that are already in service vary depending on the type of machine; older models will be phased out sooner. Many dry cleaners have already begun the transition to alternative products. The EPA rule is intended to eliminate the health risk to people that work in dry cleaning facilities. A 2009 study published in the Journal of Environmental and Public Health found that people living in buildings with a dry cleaner had higher rates of kidney cancer